Hift RJ, Meissner PN (2005) An analysis of 112 acute porphyric attacks in Cape Town,
South Africa: evidence that acute intermittent porphyria and variegate porphyria differ in
susceptibility and severity. Medicine (Baltimore) 84:48–60
Hurt K, Bilton D (2014) Inhaled interventions in cystic fibrosis: mucoactive and antibiotic
therapies. Respiration 88:441–448
Iorio F, Rittman T, Ge H et al (2013) Transcriptional data: a new gateway to drug repositioning?
Drug Discov Today 18:350–357
Jang GR, Benet LZ (1998) Antiprogestin-mediated inactivation of cytochrome P450 3A4. Pharma-
cology 56:150–157
Jiang T, Yu JT, Hu N et al (2014) CD33 in Alzheimer’s disease. Mol Neurobiol 49:529–535
Jones MR, Schrader KA, Shen Y et al (2016) Response to angiotensin blockade with irbesartan in a
patient with metastatic colorectal cancer. Ann Oncol 27:801–806
Kim JH, Scialli AR (2011) Thalidomide: the tragedy of birth defects and the effective treatment of
disease. Toxicol Sci 122:1–6
Kim YH, Beak SH, Charidimou A et al (2016) Discovering new genes in the pathways of common
sporadic neurodegenerative diseases: a bioinformatics approach. J Alzheimers Dis 51:293–312
Koromina M, Pandi M-T, Patrinos GP (2019) Rethinking drug repositioning and development with
artificial intelligence, machine learning, and omics. Omi A J Integr Biol 23:539–548.
Available from: https://www.liebertpub.com/doi/10.1089/omi.2019.0151
Kumar S, Kumar S (2019) Molecular docking: a structure-based approach for drug repurposing. In:
Silico drug design
Kwon OS, Kim W, Cha HJ et al (2019) In silico drug repositioning: from large-scale transcriptome
data to therapeutics. Arch Pharm Res 42:879–889. https://doi.org/10.1007/s12272-019-01176-3
Lau A, So HC (2020) Turning genome-wide association study findings into opportunities for drug
repositioning. Comput Struct Biotechnol J 18:1639–1650
Lavandeira A (2002) Orphan drugs: legal aspects, current situation. Haemophilia 8:194–198
Le DH, Nguyen-Ngoc D (2018) Drug repositioning by integrating known disease-gene and drug-
target associations in a semi-supervised learning model. Acta Biotheor 66:315–331
Lekka E, Deftereos SN, Persidis A et al (2011) Literature analysis for systematic drug repurposing:
a case study from Biovista. Drug Discov Today Ther Strateg 8:103–108
Lexology (2021) The IP Challenge in Patents For Repurposed Drugs and DRPx products.
Available from: https://www.lexology.com/library/detail.aspx?g¼6424901b-c7f4-40bc-8586-
4bdfed07fc33
Li YY, Jones SJM (2012) Drug repositioning for personalized medicine. Genome Med 4:27
Liu H, Lin H, Shen C et al (2020) Drug repositioning for SARS-CoV-2 based on graph neural
network. In: Proc - 2020 IEEE Int Conf Bioinforma Biomed BIBM 2020. Institute of Electrical
and Electronics Engineers Inc., pp 319–322
Mahdian S, Ebrahim-Habibi A, Zarrabi M (2020) Drug repurposing using computational methods
to identify therapeutic options for COVID-19. J Diabetes Metab Disord 19:691–699
Maletic V, Eramo A, Gwin K et al (2017) The role of norepinephrine and its α-adrenergic receptors
in the pathophysiology and treatment of major depressive disorder and schizophrenia: a
systematic review. Front Psychiatry 8:42
March-Vila E, Pinzi L, Sturm N et al (2017) On the integration of in silico drug design methods for
drug repurposing. Front Pharmacol 8:298
McClellan KJ, Markham A (1999) Finasteride: a review of its use in male pattern hair loss. Drugs
57:111–126
Mei F, Fancy SPJ, Shen Y-AA et al (2014) Micropillar arrays as a high-throughput screening
platform for therapeutics in multiple sclerosis. Nat Med 20:954–960
Mifepristone (2021) DrugBank online [Internet]. Available from: https://go.drugbank.com/drugs/
DB00834
Mirtazapine (2021) DrugBank online [Internet]. Available from: https://go.drugbank.com/drugs/
DB00370
70
I. A. Farouk et al.